Schedule Aug 31, 2003
Regulation of IP3 Receptors and Calcium Entry Pathways
Dr. Colin W. Taylor, University of Cambridge

Biphasic effects of Ca2+ on IP3 receptor function are common and widely supposed to contribute to the complex Ca2+ signals recorded from intact cells. I will present evidence from both functional and structural analyses of IP3 receptors suggesting that IP3 controls the opening of the channel by regulating Ca2+ binding to stimulatory and inhibitory Ca2+-binding sites. Ca2+ entry across the plasma membrane also contributes to the Ca2+ signals evoked by physiological stimuli. I will discuss recent results from A7r5 vascular smooth muscle cells showing that vasopressin reciprocally regulates Ca2+ entry through capacitative and non-capacitative Ca2+ entry channels via a signalling cascade that involves arachidonic acid, nitric oxide and cGMP.

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