Schedule Aug 31, 2003
Regulation of Calcium Release by Accessory Proteins
Dr. L. Roderick, Babraham Institute

Calcium is a universal intracellular messenger controlling many cellular processes from fertilisation to cell death. Changes in intracellular calcium levels are strictly governed within defined parameters. In order to regulate levels of cytosolic calcium within safe limits the cell has developed a toolkit of release channels, pumps and storage/buffering organelles. The main location of calcium storage within cells is the endoplasmic reticulum (ER) or its muscle equivalent the sarcoplasmic reticulum (SR). Calcium is primarily released from stores by the dual action calcium and Inositol, 1,4,5-trisphosphate (InsP3) on InsP3 receptors (R) or by the action of calcium alone on receptors (RyR) a process known as calcium induced calcium release (CICR). In addition to these direct modulators of channel activity, both channels are regulated by numerous accessory proteins and by secondary protein modifications such as phosphorylation. The role and mechanism of action of some of these accessory proteins will be discussed.

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