Schedule Aug 19, 2003
Growth Patterns of Microscopic Brain Tumors
Leonard Sander (University of Michigan)

Highly malignant brain tumors such as Glioblastoma Multiforme (GBM) form complex growth patterns in vitro in which invasive cells organize in tenuous branches. We formulate a model for this sort of growth. A key element controlling the pattern is homotype attraction, i.e., the tendency for invasive cells to follow pathways previously explored. Our model can give a way to assess the importance of various processes, and a way to explore and analyze transitions between different growth regimes. We also review some very recent experimental results on the formation of the growth pathways via damage and alignment of the medium in which growth occurs.

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