Jul 31, 2001
Enzymatic Signal Transduction
Dr. Boris Shraiman
The talk will review general organization of the enzymatic signal
transduction pathways in living cells and describe their function
in engineering terms. We shall identify the basic building blocks
and modules of enzymatic transduction cascades, define their
engineering characteristics such as gain, bandwidth and noise, and
observe how these characteristics can be tuned simply by adjusting
the concentrations of various enzymes. Thinking of the pathway as
an information channel defines the required engineering
characteristics and ultimately constrains the necessary amounts of
enzymes. The discussion will focus, in particular, on the
photo-transduction cascade in rod cells, the bio-chemistry of
which is among the best known. We shall also address the issues of
noise suppression, adaptation, and dynamic range and speculate on
the possible mechanisms of regulation.
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