Schedule Jul 31, 2001
Enzymatic Signal Transduction
Dr. Boris Shraiman
The talk will review general organization of the enzymatic signal transduction pathways in living cells and describe their function in engineering terms. We shall identify the basic building blocks and modules of enzymatic transduction cascades, define their engineering characteristics such as gain, bandwidth and noise, and observe how these characteristics can be tuned simply by adjusting the concentrations of various enzymes. Thinking of the pathway as an information channel defines the required engineering characteristics and ultimately constrains the necessary amounts of enzymes. The discussion will focus, in particular, on the photo-transduction cascade in rod cells, the bio-chemistry of which is among the best known. We shall also address the issues of noise suppression, adaptation, and dynamic range and speculate on the possible mechanisms of regulation.

Audio for this talk requires sound hardware, and RealPlayer or RealAudio by RealNetworks.


First part of lecture
Begin WebCam and audio: high bandwidth or medium bandwidth.
Or, begin audio only: high bandwidth or low bandwidth. (Or, right-click to download the whole audio file.)
Second part of lecture
Begin WebCam and audio: high bandwidth or medium bandwidth.
Or, begin audio only: high bandwidth or low bandwidth. (Or, right-click to download the whole audio file.)

To begin viewing slides, click on the first slide below. (Or, view as pdf.)


[01] [02] [03] [04] [05] [06] [07] [08] [09] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] [31] [32] [33] [34] [35] [36] [37] [38] [39] [40] [41] [42] [43] [44]

Author entry (protected)