Schedule Jul 23, 2001
Scales and Measurements in Neuroscience
Dr. David Kleinfeld
http://www-physics.ucsd.edu/neurophysics/
The goal is to establish basic neurophysiological principles starting, as much as possible, from basic physical principles. Biophysical scales of voltage, energy consumption, physical size, etc., will be reviewed for all aspects of the nervous system. The role of using chemical versus electrical processing will be discussed as a means to insure spatial localization of dynamics. The role of generic control for multistability in cell and synaptic function will be discussed. The role of thermal noise in setting detection limits in sensory processing as well as in biophysical measurements will be presented. We will also review classical measurement schemes, such as voltage clamp, patch recording, extracellular unit recording, the use of optical based contrast agents, and basic anatomical techniques, including classical functional techniques.

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